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Tofranil (Imipramine) is within a small grouping of drugs called tricyclic antidepressants. Imipramine affects chemicals inside the brain that will become unbalanced.
It is used to help remedy signs of depression.
This medicine may also be used for purposes besides those placed in this medication guide.


Take prescription drugs exactly as it absolutely was prescribed for you. Do not consider the medication in larger amounts, or take it for longer than recommended by your doctor. Your doctor may occasionally change your dose to successfully get the best results from medicines. Follow the directions on the prescription label.
If you might want almost any surgery, tell the surgeon ahead of time you are taking imipramine. You may need to stop while using the medicine for a short period of time.
Do not stop using imipramine without first talking to your medical professional. You may need to use less and less before you decide to stop the medication completely. Stopping this medication suddenly might lead to one to have unpleasant negative effects. It may take up to 21 days of using this medicine before your symptoms improve. For best results, keep with all the medication as directed. Talk with a medical expert if the symptoms don't improve after 30 days of treatment.

If you missed the dose take it once you remember. If it really is almost time for your next dose, skip the missed dose and consider the medicine on the next regularly scheduled time. Do not take extra medicine to generate in the missed dose.

Seek emergency medical assistance if you think maybe you might have used too much of this medicine. An overdose of imipramine can be fatal.
Symptoms of the imipramine overdose can include uneven heartbeats, extreme drowsiness, agitation, vomiting, blurred vision, sweating, muscle stiffness, swelling, lack of breath, blue lips or fingernails, feeling light-headed, fainting, seizure (convulsions), or coma.


Take this medicine as prescribed because of your doctor.


Store imipramine at room temperature from moisture and warmth.


Active Ingredient: Imipramine

Tofranil is really a tricyclic antidepressant. It works by helping the activity of certain chemicals inside the brain that assist elevate mood.

Side Effects

Get emergency medical help if you might have these signs of your allergic reaction: hives; difficulty breathing; swelling of one's face, lips, tongue, or throat.

Call a medical expert at the same time if you might have any new or worsening symptoms for example: mood or behavior changes, anxiety, anxiety attacks, sleep problems, or if you really feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your physician at once if you have all of these serious unwanted effects:

fast, pounding, or uneven pulse rate;

chest pain or heavy feeling, pain spreading on the arm or shoulder, nausea, sweating, general ill feeling;

sudden numbness or weakness, especially on one hand from the body;

sudden headache, confusion, issues with vision, speech, or balance;

feeling in short supply of breath, despite mild exertion;

swelling, rapid extra weight;

confusion, hallucinations, or seizure (convulsions);

easy bruising or bleeding, unusual weakness;

restless muscle movements inside your eyes, tongue, jaw, or neck;

urinating more or less than usual;

extreme thirst with headache, nausea, vomiting, and weakness;

skin rash, bruising, severe tingling, numbness, pain, or muscle weakness.

Less serious side effects might be very likely to occur, such as:

nausea, vomiting, stomach pain, decrease of appetite;

constipation or diarrhea;

dry mouth, unpleasant taste;

weight changes;

weakness, not enough coordination;

feeling dizzy, drowsy, or tired;


blurred vision, headache, ringing with your ears;

breast swelling (that face men or women); or

decreased sexual drive, impotence, or difficulty using an orgasm.

Tofranil is usually to be used only through the patient for whom it's prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, talk with your medical professional.


Do not use Tofranil if:

you might be allergic to the ingredient in Tofranil;

you might have taken furazolidone or possibly a monoamine oxidase inhibitor (MAOI) (e.g., phenelzine) within the last 2 weeks, or if you are taking astemizole, droperidol, or terfenadine.

you might be coping with a newly released heart attack.
Contact your medical professional or physician immediately if these apply to you.

Some medical ailments may connect to Tofranil . Tell your physician or pharmacist if you've any health conditions, particularly when any from the following connect with you:

if you're pregnant, about to get pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you've got allergies to medicines, foods, or any other substances

if you drink alcohol-containing beverages daily or you've got a history of alcohol abuse

if you're taking thyroid medicine or you might have a good overactive thyroid, glaucoma, heart problems, kidney or liver problems, diabetes, seizures, the blood disease porphyria, or difficulty urinating

if you've got a good reputation for suicidal thoughts or behavior, bipolar disorder, or some other mental disorders; you happen to be undergoing electroshock therapy; or you might be scheduled to get any surgery.

Some MEDICINES MAY INTERACT with Tofranil . Tell your health care provider if you adopt some other medicines, especially any of the following:

Azole antifungals (eg, fluconazole), cimetidine, duloxetine, flecainide, methylphenidate, mibefradil, phenothiazines (eg, chlorpromazine), propafenone, quinidine, selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine), or terbinafine given that they could raise the risk of Tofranil 's side effects

Arsenic, astemizole, droperidol, furazolidone, MAOIs (eg, phenelzine), pimozide, streptogramins (eg, dalfopristin), terfenadine, or tramadol as the probability of high blood pressure levels, serious heart disease (eg, irregular heartbeat), or seizures might be increased

Barbiturates (eg, phenobarbital) or phenytoin given that they may decrease Tofranil 's effectiveness

Anticholinergics (eg, benztropine), carbamazepine, or sympathomimetics (eg, phenylephrine) because the risk of their negative effects could be increased by Tofranil

Clonidine, guanethidine, or guanfacine as their effectiveness may be decreased by Tofranil

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