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Uses

INDICATIONS

Indinavir can be an antiviral medication inside a gang of HIV medicines called protease (PRO-tee-ayz) inhibitors. Indinavir prevents human immunodeficiency virus (HIV) cells from multiplying inside you. It is employed to treat HIV, which causes acquired immunodeficiency syndrome (AIDS). Indinavir just isn't a cure for HIV or AIDS.

INSTRUCTIONS

Take indinavir just as it had been prescribed in your case. Do not go ahead and take medication in larger amounts, or go more than recommended from your doctor. Follow the directions in your prescription label.

This medication includes patient instructions for secure and efficient use. Follow these directions carefully. Ask your doctor or pharmacist for those who have questions.
Take indinavir using a full glass (8 ounces) of water or skim milk. You might also drink juice, coffee, or tea using this medication. Drink at the very least 6 portions of water every day to prevent kidney stones when you are taking indinavir. Indinavir ought to be taken on jail stomach, a minimum of one hour before or 120 minutes after having a meal.

If you want to go ahead and take medication with food, eat just a light meal, like dry toast with jelly, or corn flakes with skim milk and sugar. Avoid eating a high-fat meal.

It is essential to work with indinavir regularly to have the most benefit. Get your prescription refilled before you run out of medication completely.

To be sure medicines is assisting your condition, your blood must be tested on a regular basis. Your liver function could also need to be tested. Do not miss any scheduled visits to your medical professional.

HIV/AIDS is generally treated using a combination of different drugs. To best treat your problem, utilise all of the medications as directed from your doctor. Be sure to read the medication guide or patient instructions supplied with each of the medications. Do not alter your doses or medication schedule without advice from your doctor. Every person with HIV or AIDS should remain under the proper care of a physician.

Take the missed dose whenever you remember and take your following dose with the regularly scheduled time. If you are greater than 2 hours late in taking your indinavir, skip the missed dose and consider the next regularly scheduled dose. Do not take extra medicine to generate inside the missed dose.

DOSAGE

Usual Adult Dose for HIV Infection
800 mg orally every 8 hours or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours.


Usual Adult Dose for Nonoccupational Exposure
800 mg orally every 8 hours or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours.
Duration: Prophylaxis ought to be initiated immediately, within 72 hours of exposure, and continued for 28 days.
Indinavir plus ritonavir plus 2 NRTIs is amongst the alternative regimens suitable for nonoccupational postexposure HIV prophylaxis.


Usual Adult Dose for Occupational Exposure
800 mg orally every 8 hours 800 mg orally every 8 hours plus lamivudine-zidovudine,
or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours plus lamivudine-zidovudine.
Duration: Therapy must start promptly, preferably within 1 to 2 hours postexposure. The exact amount of therapy could differ based on the institution's protocol.

Liver Dose Adjustments
Mild to moderate hepatic insufficiency: 600 mg orally every 8 hours.


Dose Adjustments
Consider reducing the dose to 600 mg every 8 hours if delavirdine, itraconazole, or ketoconazole are administered concomitantly. Increase the dose to 1000 mg every 8 hours if rifabutin is offered concurrently, and decrease the rifabutin dose by half.
Precautions

Strict adherence towards the prescribed dose is essential. Patients ought not affect the dose or discontinue therapy without talking to their physician.

Adequate hydration (1.5 liters/day) is essential during therapy to cut back the potential risk of nephrolithiasis. A brief interruption (usually 1 to 3 days) or total discontinuation could be necessary if nephrolithiasis occurs.

Discontinue indinavir if hemolytic anemia occurs. Consider discontinuation if severe leukocyturia develops.

STORAGE

Store indinavir at room temperature away from moisture and warmth. Keep the capsules inside their original container, combined with packet of moisture-absorbing preservative that is sold with indinavir capsules.

Side Effects

Get emergency medical help in case you have some of these signs and symptoms of a hypersensitivity: hives; breathlessness; swelling of your face, lips, tongue, or throat. Stop taking indinavir and call your physician simultaneously when you have any of these serious negative effects:

Less serious side effects can include:

This isn't a complete list of side effects while others may occur. Tell your medical professional about any unusual or bothersome side effect.

Precautions

Do not take medicines should you be allergic to indinavir.
Do not take indinavir with amiodarone (Cordarone, Pacerone), cisapride (Propulsid), pimozide (Orap), alprazolam (Xanax), oral midazolam (Versed), triazolam (Halcion), or ergot medicines for example ergotamine (Ergomar, Cafergot), dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), or methylergonovine (Methergine). These drugs may cause life-threatening unwanted side effects if you use them when you are taking indinavir.

Before taking indinavir, tell a medical expert should you be allergic to the drugs, or for those who have:

If you have some of these conditions, you need a dose adjustment or special tests to securely take indinavir.
FDA pregnancy category C. This medication could be bad for an child. Tell your medical professional should you be pregnant or want to conceive during treatment. HIV may be passed to the baby if your mother just isn't properly treated when pregnant. Take all of the HIV medicines as forwarded to overcome your infection when you are pregnant.

Your name may need to be for auction on an antiviral pregnancy registry when you start using prescription drugs.
You must not breast-feed while you are using indinavir. Women with HIV or AIDS shouldn't breast-feed in any way. Even if your child arrives without HIV, you might still pass the virus towards the baby inside your breast milk.


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