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Precautions

Do NOT use Clozaril if:

• you might be allergic to your ingredient in Clozaril
• you've bone marrow problems, other blood cell problems, or possibly a reputation blood problems brought on by Clozaril
• you might have uncontrolled seizures (eg, epilepsy) or decrease of bowel muscle movement (paralytic ileus)
• you've got severe drowsiness
• you consider other medicines that could cause blood problems. Ask your medical professional if you are unsure if many medicines could potentially cause blood problems.

Contact a medical expert or health care provider right away if all of these affect you.

Some medical conditions may connect to Clozaril. Tell your medical professional or pharmacist when you have any medical conditions, especially if any from the following sign up for you:

• should you be pregnant, likely to conceive, or are breast-feeding
• if you take any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• for those who have allergies to medicines, foods, and other substances
• for those who have a reputation blood clots, blood problems, high blood cholesterol, heart related illnesses, or lung or breathing problems
• in case you have a history associated with an enlarged prostate; prolonged, painful erections; liver or kidney problems; seizures (eg, epilepsy); glaucoma; stomach or bowel obstruction; or dementia
• for those who have poor health, diabetes, or a relative with diabetes, or you might be very overweight
• in case you have decreased activity of enzymes that metabolize certain medicines.

Some medicines may connect to Clozaril. Tell your doctor if you take every other medicines, especially any from the following:

• Benzodiazepines (eg, lorazepam) and other medicines for mental or mood problems since the chance of heart or breathing problems might be increased
• Cimetidine, erythromycin, quinolone antibiotics (eg, ciprofloxacin), risperidone, or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because they might increase the likelihood of Clozaril's negative effects
• Barbiturates (eg, phenobarbital), hydantoins (eg, phenytoin), nicotine, or rifampin given that they may decrease Clozaril's effectiveness
• Antiarrhythmics (eg, propafenone, quinidine), anticholinergics (eg, benztropine), carbamazepine, debrisoquin, dextromethorphan, medicines for depression or high blood pressure, phenothiazines (eg, chlorpromazine), or tricyclic antidepressants (eg, amitriptyline) because the chance of their side effects could be increased by Clozaril.

This may not be an entire list of all interactions that may occur. Ask your health care provider if Clozaril may communicate with other medicines that you take. Check with your doctor before starting, stop, or change the dose associated with a medicine.

Important safety information:

• Clozaril may cause drowsiness, dizziness, or lightheadedness. These effects could be worse if you take it with alcohol or certain medicines. Use Clozaril with caution. Do not drive or perform other possible unsafe tasks until you recognize how you respond to it.
• Do not use alcohol or medicines that could potentially cause drowsiness (eg, sleep aids, muscle relaxers) while you taking Clozaril. It may enhance their effects. Ask your pharmacist for those who have questions about which medicines might cause drowsiness.
• Clozaril could potentially cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, crunches or stand slowly, especially inside morning. Sit or sleep the night at the first symbol of all of these effects.
• Clozaril may lower the ability of one's body to battle infection. Avoid experience of those who have colds or infections. Tell a medical expert right away possibly any signs and symptoms of infection like fever, sore throat, rash, chills, mouth or nose sores, or unusual tiredness or weakness.
• Women and patients of Jewish background could possibly be at greater probability of developing blood issues with Clozaril.
• If you have a reputation seizures, you could suddenly lose conscious while you take Clozaril. Avoid activities through which loss of conscious could possibly be dangerous to you personally or others (eg, driving, swimming, climbing, operating machinery).
• Clozaril may raise your blood glucose levels. High blood glucose levels may make you are feeling confused, drowsy, or thirsty. It can also cause you to flush, breathe faster, or possess a fruit-like breath odor. If these symptoms occur, tell a medical expert right away.
• Avoid drink and food an excellent source of caffeine, like coffee, tea, cocoa, cola, and chocolate.
• Tell your physician or dentist that you simply take Clozaril. It could impact the medical or dental hygiene, emergency care, or surgery you might receive.
• Neuroleptic malignant syndrome (NMS) can be a possibly fatal syndrome that can be caused by Clozaril. Symptoms can sometimes include fever, stiff muscles, confusion, abnormal thinking, fast or irregular heartbeat, and sweating. Contact a medical expert simultaneously for those who have any of these symptoms.
• Some patients having Clozaril may develop muscle movements that they can cannot control. This is more likely to occur in elderly patients, especially women. The chance until this could happen or that it's going to become permanent is greater in those taking Clozaril in high doses or for quite a while. Muscle problems might also occur after short-term treatment with low doses. Tell your physician simultaneously if you have muscle problems together with your tongue, face, mouth, jaw (eg, tongue herniated, puffing of cheeks, mouth puckering, chewing movements), arms, or legs while taking Clozaril.
• Lab tests, including complete blood cell counts and heart function tests, might be performed to watch your progress or search for negative effects. Be sure to keep all doctor and lab appointments.
• Use Clozaril with caution inside the elderly; they could be more sensitive to its effects, especially blood problems, dizziness (especially upon standing), fast heartbeat, urinary problems, and constipation.
• Clozaril ought to be in combination with warning in children; safety and effectiveness in children weren't determined.
• Pregnancy and breast-feeding: If you conceive, contact your doctor. You will need to discuss the advantages and perils of using Clozaril while you happen to be pregnant. It is not known if Clozaril is found in breast milk. Do not breastfeed while taking Clozaril.