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Precautions

Do NOT use Clozaril if:

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• you've got bone marrow problems, other blood cell problems, or even a good blood problems caused by Clozaril

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• you might have uncontrolled seizures (eg, epilepsy) or decrease of bowel muscle movement (paralytic ileus)
• you might have severe drowsiness

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• you consider other medicines that may cause blood problems. Ask your doctor if you're unsure if many medicines may cause blood problems.

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Contact your physician or physician without delay if all of these sign up for you.

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Some health conditions may interact with Clozaril. Tell a medical expert or pharmacist in case you have any health concerns, particularly if any in the following apply to you:

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• in case you are pregnant, intending to get pregnant, or are breast-feeding

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• if you have a good blood clots, blood problems, high blood cholesterol levels, cardiovascular disease, or lung or breathing problems
• if you have a history of your enlarged prostate; prolonged, painful erections; liver or kidney problems; seizures (eg, epilepsy); glaucoma; stomach or bowel problems; or dementia

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• when you have bad health, diabetes, or a family member with diabetes, or you happen to be very overweight
• when you have decreased activity of enzymes that metabolize certain medicines.

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Some medicines may communicate with Clozaril. Tell your health care provider if you are taking another medicines, especially any of the following:

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• Benzodiazepines (eg, lorazepam) and other medicines for mental or mood problems as the chance of heart or breathing problems could be increased

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• Cimetidine, erythromycin, quinolone antibiotics (eg, ciprofloxacin), risperidone, or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because they might increase the likelihood of Clozaril's unwanted effects

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• Barbiturates (eg, phenobarbital), hydantoins (eg, phenytoin), nicotine, or rifampin because they may decrease Clozaril's effectiveness

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• Antiarrhythmics (eg, propafenone, quinidine), anticholinergics (eg, benztropine), carbamazepine, debrisoquin, dextromethorphan, medicines for depression or high blood pressure levels, phenothiazines (eg, chlorpromazine), or tricyclic antidepressants (eg, amitriptyline) since the risk of their unwanted effects could be increased by Clozaril.

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This is probably not a total set of all interactions that may occur. Ask your medical provider if Clozaril may talk with other medicines that you just take. Check together with your physician before starting, stop, or change the dose from a medicine.

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Important safety information:

• Clozaril might cause drowsiness, dizziness, or lightheadedness. These effects could possibly be worse if you go on it with alcohol or certain medicines. Use Clozaril with caution. Do not drive or perform other possible unsafe tasks before you know how you reply to it.

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• Do not use alcohol or medicines that could potentially cause drowsiness (eg, sleep aids, muscle relaxers) whilst you taking Clozaril. It may enhance their effects. Ask the pharmacist for those who have questions regarding which medicines could potentially cause drowsiness.

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• Clozaril may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, crunches or stand slowly, especially within the morning. Sit or lay down in the first symbol of these effects.

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• Clozaril may lower the ability of the body to fight infection. Avoid exposure to people who have colds or infections. Tell a medical expert without delay if you notice any signs and symptoms of infection like fever, sore throat, rash, chills, mouth or nose sores, or unusual tiredness or weakness.
• Women and patients of Jewish background could be at greater probability of developing blood difficulties with Clozaril.

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• If you've a history of seizures, you might suddenly lose conscious as you consider Clozaril. Avoid activities through which loss in conscious may be dangerous to you kinds (eg, driving, swimming, climbing, operating machinery).

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• Neuroleptic malignant syndrome (NMS) is a possibly fatal syndrome that can be a result of Clozaril. Symptoms can sometimes include fever, stiff muscles, confusion, abnormal thinking, fast or irregular heartbeat, and sweating. Contact your physician at once in case you have all of these symptoms.
• Some patients who take Clozaril may develop muscle movements that they can cannot control. This is very likely to take place in elderly patients, especially women. The chance until this may happen or that it's going to become permanent is greater in those taking Clozaril in high doses and quite a long time. Muscle problems could also occur after short-term treatment with low doses. Tell your physician at the same time if you have muscle problems using your tongue, face, mouth, jaw (eg, tongue protruding, puffing of cheeks, mouth puckering, chewing movements), arms, or legs while taking Clozaril.
• Lab tests, including complete blood cell counts and heart function tests, could be performed to monitor your progress or search for negative effects. Be sure to keep all doctor and lab appointments.

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