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Precautions

Do NOT use Clozaril if:

• you might be allergic to any ingredient in Clozaril
• you've got bone marrow problems, other blood cell problems, or possibly a good reputation for blood problems caused by Clozaril
• you've got uncontrolled seizures (eg, epilepsy) or lack of bowel muscle movement (paralytic ileus)
• you have severe drowsiness
• you are taking other medicines that may cause blood problems. Ask your medical professional should you be unsure if any medicines may cause blood problems.

Contact a medical expert or health care provider without delay if these sign up for you.

Some health conditions may connect to Clozaril. Tell your medical professional or pharmacist if you have any health conditions, particularly when any in the following apply to you:

• if you are pregnant, about to become pregnant, or are breast-feeding
• if you consider any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• for those who have allergies to medicines, foods, or another substances
• when you have a reputation blood clots, blood problems, high blood cholesterol levels, cardiovascular disease, or lung or breathing problems
• when you have a history of an enlarged prostate; prolonged, painful erections; liver or kidney problems; seizures (eg, epilepsy); glaucoma; stomach or irregularity; or dementia
• if you have illness, diabetes, or even a member of the family with diabetes, or you are very overweight
• in case you have decreased activity of enzymes that metabolize certain medicines.

Some medicines may interact with Clozaril. Tell your medical provider if you are taking every other medicines, especially any with the following:

• Benzodiazepines (eg, lorazepam) or any other medicines for mental or mood problems as the chance of heart or breathing problems might be increased
• Cimetidine, erythromycin, quinolone antibiotics (eg, ciprofloxacin), risperidone, or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) since they could raise the likelihood of Clozaril's unwanted effects
• Barbiturates (eg, phenobarbital), hydantoins (eg, phenytoin), nicotine, or rifampin because they may decrease Clozaril's effectiveness
• Antiarrhythmics (eg, propafenone, quinidine), anticholinergics (eg, benztropine), carbamazepine, debrisoquin, dextromethorphan, medicines for depression or high blood pressure levels, phenothiazines (eg, chlorpromazine), or tricyclic antidepressants (eg, amitriptyline) since the chance of their unwanted side effects may be increased by Clozaril.

This may not be a complete listing of all interactions that could occur. Ask your doctor if Clozaril may connect to other medicines that you simply take. Check together with your doctor before you start, stop, or customize the dose from a medicine.

Important safety information:

• Clozaril could potentially cause drowsiness, dizziness, or lightheadedness. These effects might be worse if you get it with alcohol or certain medicines. Use Clozaril with caution. Do not drive or perform other possible unsafe tasks unless you recognize how you react to it.
• Do not use alcohol or medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) when you taking Clozaril. It may improve their effects. Ask the pharmacist if you have questions regarding which medicines may cause drowsiness.
• Clozaril might cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially inside morning. Sit or sleep the night with the first symbol of all of these effects.
• Clozaril may lower the ability of your body to address infection. Avoid experience of folks who suffer from colds or infections. Tell a medical expert immediately possibly any signs and symptoms of infection like fever, sore throat, rash, chills, mouth or nose sores, or unusual tiredness or weakness.
• Women and patients of Jewish background may be at greater risk of developing blood issues with Clozaril.
• If you've a good seizures, you could suddenly lose conscious while you consider Clozaril. Avoid activities where decrease of conscious might be dangerous for you varieties (eg, driving, swimming, climbing, operating machinery).
• Clozaril may raise the blood sugar levels. High blood glucose levels may make you are feeling confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your physician straight away.
• Avoid drink and food full of caffeine, like coffee, tea, cocoa, cola, and chocolate.
• Tell a medical expert or dentist that you just take Clozaril. It could have an impact on the medical or dental hygiene, emergency care, or surgery you may receive.
• Neuroleptic malignant syndrome (NMS) is often a possibly fatal syndrome that could be a result of Clozaril. Symptoms may include fever, stiff muscles, confusion, abnormal thinking, fast or irregular heartbeat, and sweating. Contact your doctor at the same time when you have all of these symptoms.
• Some patients having Clozaril may develop muscle movements that they cannot control. This is more likely to happen in elderly patients, especially women. The chance that this may happen or that it will become permanent is greater in those taking Clozaril in high doses and a very long time. Muscle problems could also occur after short-term treatment with low doses. Tell your medical professional simultaneously in case you have muscle problems along with your tongue, face, mouth, jaw (eg, tongue sticking out, puffing of cheeks, mouth puckering, chewing movements), arms, or legs while taking Clozaril.
• Lab tests, including complete blood cell counts and heart function tests, could possibly be performed to monitor your progress or search for unwanted side effects. Be sure to keep all doctor and lab appointments.
• Use Clozaril with caution inside elderly; they might be more understanding of its effects, especially blood problems, dizziness (especially upon standing), fast heartbeat, urinary problems, and constipation.
• Clozaril must be used in combination with warning in kids; safety and effectiveness in kids weren't determined.
• Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the advantages and perils of using Clozaril while you are pregnant. It is not known if Clozaril is found in breast milk. Do not breastfeed while taking Clozaril.