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ARAVA is indicated in adults for the management of active rheumatism (RA):


Take this medicine only as directed from your doctor. Do not take a greater portion of it, don't take it more frequently, and don't take it for a longer time than a medical expert ordered.

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The dose of the medicine will change for several patients. Follow your physician's orders or even the directions about the label. The following information includes only the average doses with this medicine. If your dose is unique, usually do not change it unless your medical professional tells you to take action.

The level of medicine that you simply take depends around the strength of the medicine. Also, the volume of doses you are taking on a daily basis, enough time allowed between doses, along with the time period you're taking the medicine depend around the medical problem that you can are choosing the medicine.

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For oral dosage form (tablets):

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For rheumatism:

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If you miss a dose on this medicine, get it immediately. However, whether it is almost time for your upcoming dose, skip the missed dose and get back to your family dosing schedule. Do not double doses.

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Store at 25°C (77°F); excursions permitted 15-30°C (59-86°F). Protect from light. Keep out in the reach of children. Do not keep outdated medicine or medicine don't needed. Store the medicine in the closed container at room temperature, from heat, moisture.

 Keep out in the reach of kids. Do not keep outdated medicine or medicine no longer needed. Store the medicine inside a closed container at room temperature, far from heat, moisture.


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Side Effects

Stop applying this medicine and look with a medical expert straight away should you be having burning, numbness, tingling, or painful sensations inside the arms, hands, legs, or feet. These could be symptoms of a condition called peripheral neuropathy.

Adverse reactions from the usage of leflunomide in RA include diarrhea, elevated liver enzymes (ALT and AST), alopecia and rash.

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Along featuring its needed effects, medication could cause some uncomfortable side effects. Although not all of these side effects may occur, should they happen they could need medical assistance.

Check with your doctor immediately if any in the following unwanted effects occur:
More common
Bloody or cloudy urine
difficult or painful breathing
difficult, burning, or painful urination
frequent urge to urinate
loss of appetite
feeling sick
sore throat
tightness inside chest
yellow eyes or skin
Less common
Burning feeling inside chest or stomach
burning, prickling, or tingling sensation inside the fingers or toes
chest pain
fast heartbeat
joint or muscle pain or stiffness
pounding heartbeat
severe stomach pain
tenderness inside the stomach area
unusual tiredness or weakness
Incidence mysterious
Area rash
black or tarry stools
bleeding gums
blistering, peeling, or loosening from the skin
blood inside stools
burning, numbness, tingling, or painful sensations
clay-colored stools
continuing vomiting
cough or hoarseness
dark urine
fever with or without chills
general a sense tiredness or weakness
high fever
large, hive-like swelling about the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
light-colored stools
spine or side pain
pains in the stomach, side, or abdomen, possibly radiating to the back
pale skin
pinpoint red spots on the skin
rapid, shallow breathing
red wounds, often having a purple center
red, irritated eyes
sores, ulcers, or white spots inside mouth or on the lips
swollen glands
unexplained bleeding or bruising
unpleasant breath odor
unsteadiness or awkwardness
unusual bleeding or bruising
upper right abdominal or stomach pain
vomiting of blood
weakness in the arms, hands, legs, or feet

Some unwanted side effects may occur that always usually do not need medical attention. These unwanted effects might have to go away during treatment because your body adjusts to the medicine. Also, your overall health care professional could possibly tell you about approaches to prevent or reduce some unwanted side effects. Check with your health care professional if any in the following side effects continue or are bothersome or if you have any queries about them:
More common
Back pain
hair loss
skin rash
stomach pain
weight loss (unexplained)
Less common
decreased appetite
dry mouth
irritation or soreness in the mouth
itching in the skin
pain or burning within the throat
runny nose

Other unwanted side effects unlisted may also appear in some patients. If you notice any other effects, check together with your medical practioner.

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It is vital that your doctor look at your progress at regular visits to ensure that this prescription medication is in working order. Blood tests may be required to check for negative effects.

Using this medicine if you are pregnant can harm your baby. Use an effective kind of contraception to keep from conceiving. If you think you might have get pregnant when using the medicine, tell your doctor immediately.

Leflunomide can also cause birth defects if the father is utilizing it when his sexual partner becomes pregnant. Men taking leflunomide should use condoms like a type of contraception during sexual activity. A man planning to father a youngster should stop taking this medicine and appearance together with his doctor immediately.

Serious skin reactions can occur using this medicine. Stop applying this medicine and look with your physician immediately if you've got any with the following symptoms while using this medicine: blistering, peeling, or loosening of the skin; chills; itching; joint or muscle pain; red skin lesions, often with a purple center; sores, ulcers, or white spots in the mouth or on the lips; or unusual tiredness or weakness.

Liver problems may occur while you are employing this medicine. Stop applying this medicine and check with a medical expert without delay if you're having more than one of such symptoms: abdominal or stomach pain or tenderness; clay-colored stools; dark urine; decreased appetite; fever; headache; decrease of appetite; nausea / vomiting; skin rash; swelling from the feet or lower legs; unusual tiredness or weakness; or yellow eyes or skin.

Leflunomide can temporarily lower the number of white blood cells with your blood, improving the potential for getting infection. It can also lower the volume of platelets, which are essential for proper blood clotting. If this occurs, there are specific precautions you are able to take, especially when your blood count is low, to relieve the chance of infection or bleeding:

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Check with your doctor immediately if you've a cough with or without temperature, lack of breath, or any difficulty with breathing.

You have to have a skin test for tuberculosis before you begin employing this medicine. Tell your physician should you or anyone with your home has had a positive reaction to a tuberculosis test.

Using this medicine may raise your chance of getting serious infections or cancer. Talk to your doctor if you have concerns about this risk.

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Do not take other medicines unless to remain discussed with a medical expert. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

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