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ARAVA is indicated in adults for the management of active arthritis rheumatoid (RA):


Take this medicine only as directed because of your doctor. Do not take really it, don't take it often, and don't take on it a bit longer than your medical professional ordered.

The dose of the medicine changes for several patients. Follow your physician's orders or perhaps the directions about the label. The following information includes exactly the average doses of this medicine. If your dose differs from the others, do not change it unless a medical expert lets you know to do this.

The amount of medicine that you take depends about the strength with the medicine. Also, the amount of doses you take every day, some time allowed between doses, along with the length of time you take the medicine depend for the disease that you are choosing the medicine.

For oral dosage form (tablets):

For arthritis rheumatoid:

If you miss a dose with this medicine, go immediately. However, if it is almost time for your forthcoming dose, skip the missed dose and get back on your regular dosing schedule. Do not double doses.


Store at 25°C (77°F); excursions permitted 15-30°C (59-86°F). Protect from light. Keep out with the reach of children. Do not keep outdated medicine or medicine will no longer needed. Store the medicine in a closed container at room temperature, from heat, moisture.

 Keep out from the reach of children. Do not keep outdated medicine or medicine don't needed. Store the medicine inside a closed container at room temperature, from heat, moisture.


Side Effects

Stop applying this medicine and check with your physician without delay in case you are having burning, numbness, tingling, or painful sensations within the arms, hands, legs, or feet. These could be the signs of a condition called peripheral neuropathy.

Adverse reactions for this utilization of leflunomide in RA include diarrhea, elevated liver enzymes (ALT and AST), alopecia and rash.

Along with its needed effects, medicines may cause some unwanted side effects. Although not these negative effects may occur, when they occur they will often need medical help.

Check with your physician immediately if any of the following side effects occur:
More common
Bloody or cloudy urine
difficult or painful breathing
difficult, burning, or painful urination
frequent urge to urinate
loss of appetite
nausea or vomiting
sore throat
tightness within the chest
yellow eyes or skin
Less common
Burning feeling inside chest or stomach
burning, prickling, or tingling sensation inside the fingers or toes
chest pain
fast heartbeat
joint or muscle pain or stiffness
pounding heartbeat
severe stomach pain
tenderness inside the stomach area
unusual tiredness or weakness
Incidence not known
Area rash
black or tarry stools
bleeding gums
blistering, peeling, or loosening with the skin
blood inside stools
burning, numbness, tingling, or painful sensations
clay-colored stools
continuing vomiting
cough or hoarseness
dark urine
fever with or without chills
general a feeling of tiredness or weakness
high fever
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
light-colored stools
spine or side pain
pains inside the stomach, side, or abdomen, possibly radiating for the back
pale skin
pinpoint red spots for the skin
rapid, shallow breathing
red wounds, often using a purple center
red, irritated eyes
sores, ulcers, or white spots within the mouth or about the lips
swollen glands
unexplained bleeding or bruising
unpleasant breath odor
unsteadiness or awkwardness
unusual bleeding or bruising
upper right abdominal or stomach pain
vomiting of blood
weakness within the arms, hands, legs, or feet

Some unwanted side effects may occur have a tendency to usually do not need medical help. These unwanted side effects might go away during treatment because your body adjusts on the medicine. Also, your wellbeing care professional just might share with you methods to prevent or reduce a few of these side effects. Check together with your health care professional if any with the following unwanted side effects continue or are bothersome or if you've got questions about them:
More common
Back pain
hair loss
skin rash
stomach pain
weight loss (unexplained)
Less common
decreased appetite
dry mouth
irritation or soreness from the mouth
itching of the skin
pain or burning inside the throat
runny nose

Other unwanted effects unlisted may also occur in some patients. If you notice some other effects, check using your medical practioner.



It is very important that your physician look at the progress at regular visits to make certain that this drugs are working properly. Blood tests may be required to evaluate for unwanted effects.

Using this medicine if you are pregnant damages your baby. Use an effective type of birth control to hold from having a baby. If you think you might have become pregnant with all the medicine, tell your doctor immediately.

Leflunomide can also cause birth defects if your father is utilizing it when his sexual partner becomes pregnant. Men taking leflunomide should use condoms like a type of contraception during sex. A man intending to father a kid should stop using this medicine and check with his doctor right away.

Serious skin reactions can happen using this medicine. Stop employing this medicine and look with your medical professional without delay if you might have any with the following symptoms while using this medicine: blistering, peeling, or loosening in the skin; chills; itching; joint or muscle pain; red skin lesions, often using a purple center; sores, ulcers, or white spots inside mouth or around the lips; or unusual tiredness or weakness.

Liver problems may occur while you are choosing this medicine. Stop applying this medicine and check with your doctor right away in case you are having several of these symptoms: abdominal or stomach pain or tenderness; clay-colored stools; dark urine; decreased appetite; fever; headache; lack of appetite; queasiness; skin rash; swelling in the feet or calves; unusual tiredness or weakness; or yellow eyes or skin.

Leflunomide can temporarily lower the volume of white blood cells within your blood, enhancing the potential for getting an infection. It can also lower the quantity of platelets, which can be essential for proper blood clotting. If this occurs, a number of precautions you can take, particularly if your blood count is low, to relieve the chance of infection or bleeding:

Check with a medical expert without delay if you've a cough with or without temperature, shortness of breath, or any issue with breathing.

You should have a skin test for tuberculosis before starting by using this medicine. Tell your doctor if you or anyone with your home has had a good reaction to a tuberculosis test.

Using this medicine may improve your likelihood of getting serious infections or cancer. Talk to your medical professional if you've concerns relating to this risk.

Do not take other medicines unless to remain discussed with your medical professional. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or nutritional vitamin supplements.

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