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Precautions

Do NOT use Zestoretic if:

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• you happen to be allergic to your ingredient in Zestoretic or other sulfonamide medicine (eg, sulfamethoxazole, glyburide, probenecid)
• you have a history of angioedema (swelling from the face, lips, throat, or tongue)

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• you possess a good kidney artery narrowing

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• you cannot urinate

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• you take dofetilide or ketanserin

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• you're pregnant.

Contact your physician or physician straight away if all of these connect with you.

Some medical conditions may connect to Zestoretic. Tell your medical professional or pharmacist when you have any health conditions, particularly if any in the following connect with you:

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• if you might be pregnant, likely to become pregnant, or are breast-feeding

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• should you consider any prescription or nonprescription medicine, herbal preparation, or dietary supplement

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• for those who have allergies to medicines, foods, or other substances

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• if you might be able to become pregnant

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• when you have impaired liver function, blood vessel problems (eg, stroke), coronary disease (eg, congestive heart failure), or high cholesterol

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• in case you have a good reputation for kidney artery narrowing or decreased kidney function, you're on dialysis, or you've had a kidney transplant
• in case you have gout, diabetes, or electrolyte imbalances (eg, high or low potassium levels, low blood sodium levels), or you might be on the sodium-restricted diet

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• should you possess a collagen vascular disorder (eg, lupus, scleroderma), bone marrow problems, or severe defense mechanisms problems

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• in the event you have a history of allergies or asthma
• if you're scheduled to get major surgery or receive anesthesia.

Some medicines may talk with Zestoretic. Tell your medical provider if you are taking every other medicines, especially any from the following:

• Aldosterone blockers (eg, eplerenone), corticosteroids (eg, prednisone), digoxin, dofetilide, ketanserin, lithium, loop diuretics (eg, furosemide), potassium preparations, potassium-sparing diuretics (eg, triameterene), or trimethoprim because the chance of electrolyte problems and irregular heartbeat might be increased

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• Barbiturates (eg, phenobarbital), dextran sulfate, diazoxide, or narcotic pain medicine (eg, codeine) for the reason that probability of low blood pressure levels could possibly be increased
• Gold-containing medicines (eg, sodium aurothiomalate) because flushing, nausea, vomiting, and low blood pressure may occur

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• Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, indomethacin, celecoxib) or salicylates (eg, aspirin) since they may decrease Zestoretic's effectiveness
• Insulin, sulfonylureas (eg, glyburide), or other medicines for diabetes (eg, metformin) as their effectiveness could possibly be decreased by Zestoretic.

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This will not be a whole set of all interactions that could occur. Ask your health care provider if Zestoretic may communicate with other medicines that you take. Check with your health care provider prior to starting, stop, or change the dose associated with a medicine.

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Important safety information:

• Zestoretic may cause dizziness, lightheadedness, or fainting. These effects may be worse if you take it with alcohol or certain medicines. Use Zestoretic with caution. Do not drive or perform other possible unsafe tasks unless you understand how you react for it.

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• Zestoretic might cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, crunch or stand slowly, especially within the morning. Sit or lay down in the first sign associated with a of these effects.

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• Check using your doctor when you use a salt substitute or perhaps a creation that has potassium inside it.

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• Drink a good amount of fluids while taking Zestoretic and steer clear of starting activities that induce hyperhidrosis. Dehydration, sweating in excess, vomiting, or diarrhea can lead to a fall in blood pressure level. Contact your doctor at the same time if some of these occur.

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• Diabetes patients - Zestoretic may raise your blood sugar levels. High blood glucose levels might make you are feeling confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your physician straight away.
• A persistent, unproductive cough may occur. Tell your physician if this occurs. Recovery is rapid in the event the medicine is stopped.
• Patients who take medicine for high blood pressure often feel tired or run-down for a couple of weeks after starting treatment. Be sure to take your medicine even though you may well not feel "normal." Tell your physician if you develop any new symptoms.

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• Zestoretic may well not act as well in black patients. They may also be at greater likelihood of unwanted side effects. Contact your doctor if the symptoms usually do not improve or if they become worse.

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• Tell your physician or dentist that you're taking Zestoretic before you decide to get any medical or dental care, emergency care, or surgery.

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• Zestoretic could potentially cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you understand how you reply to Zestoretic. Use a sunscreen or wear protective clothing should you has to be outside for more than a short period of time.

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• Zestoretic may interfere with certain lab tests, including parathyroid function tests. Be sure your physician and lab personnel know you consider Zestoretic.

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• Lab tests, including blood electrolytes, blood pressure levels, complete blood cell counts, and kidney function, could be performed while you use Zestoretic. These tests may be used to monitor your condition or pay attention to side effects. Be sure to keep all doctor and lab appointments.
• Use Zestoretic with caution within the elderly; they could possibly be more responsive to its effects.

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• Zestoretic should be used with extreme caution in youngsters; safety and effectiveness in children have not been confirmed.
• Pregnancy and breast-feeding: Zestoretic may cause birth defects or fetal death if you're taking it while you are pregnant. If you think you may be pregnant, speak to your doctor right away. Zestoretic is situated in breast milk. Do not breastfeed while taking Zestoretic.

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