Generic Motilium is utilized to supress nausea and nausea, and works primarily by blocking dopamine receptors based in the upper end of the digestive system. This causes tightening of the muscles at the entry to the stomach, relaxation of the muscles at the exit of the stomach and increased contraction of the muscles in the stomach itself. These actions speed up the passage of food through the stomach into the intestine, which physically helps prevent vomiting and reduces feelings of sickness, bloating and fullness. It also prevents food from flowing the wrong way through the stomach therefore prevents reflux (regurgitation of the stomach articles right back into the foodpipe).
Negative effects consist of:
Since domperidone is highly metabolised in the liver, domperidone should be utilized with caution in patients with hepatic impairment (and in the elderly).
Domperidone ought to be used with caution in patients with renal impairment or in those at risk of water retention. In patients with severe renal insufficiency (serum creatinine more than 6mg/100ml, i.e. more than 0,6mmol/L) the elimination half-life of domperidone was increased from 7,4 to 20,8 hours. The dosing frequency should be reduced to once or twice daily, depending on the severity of impairment, and the dose may require to be paid off. Patients on prolonged therapy should be reviewed regularly.
Airmail: 2-3 weeks, EMS: 3-8 business days.