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Precautions

Do NOT use Methotrexate if:

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• you're treating psoriasis or rheumatoid arthritis and you are pregnant or breast-feeding

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• you might be treating psoriasis or rheumatoid arthritis and abuse alcohol or have liver problems, an immunodeficiency syndrome (eg, AIDS), bone marrow problems, or blood problems (eg, anemia, low white blood cell count, low platelet count)

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• you've got moderate or severe kidney problems

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• you are taking acitretin.

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Contact a medical expert or health care provider without delay if these affect you.

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Some health conditions may communicate with Methotrexate. Tell a medical expert or pharmacist when you have any medical ailments, in particular when any of the following affect you:

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• if you're pregnant, planning to get pregnant, or are breastfeeding

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• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

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• in case you have allergies to medicines, foods, or other substances
• for those who have a good reputation for lung problems, disease fighting capability problems, nervous system problems (eg, seizures), liver problems (eg, hepatitis), or blood problems (eg, anemia, low white blood cells, low blood platelets)

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• if you have an active infection, severe vomiting or diarrhea, or dehydration
• when you have mouth sores, excess fluid in your stomach or around your lungs, stomach or intestinal ulcers, bowel inflammation (eg, ulcerative colitis), or perhaps a blockage of one's stomach or bowel

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• for those who have a folate deficiency, come in very poor health, or have a very good reputation for alcohol abuse

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Some medicines may communicate with Methotrexate. Tell your medical provider in case you are taking some other medicines, especially any from the following:

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• Acitretin, azathioprine, etretinate, leflunomide, retinoids, or sulfasalazine because the probability of liver problems may be increased

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• Chloramphenicol, corticosteroids (eg, prednisone), cyclosporine, dantrolene, hydantoins (eg, phenytoin), nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, celecoxib), penicillin antibiotics, phenylbutazone, pristinamycin, probenecid, quinolone antibiotics (eg, ciprofloxacin), salicylates (eg, aspirin), sulfonamides (eg, sulfamethoxazole), tetracycline, or trimethoprim because they may increase the probability of Methotrexate's side effects

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• Folic acid or leucovorin since they may decrease Methotrexate's effectiveness
• Digoxin because its effectiveness may be decreased by Methotrexate

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• Anticoagulants (eg, warfarin), cyclosporine, or theophylline since the chance of their unwanted effects could possibly be increased by Methotrexate.

This might not be a whole set of all interactions that could occur. Ask your doctor if Methotrexate may interact with other medicines that you simply take. Check together with your health care provider before you start, stop, or customize the dose of any medicine.

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Important safety information:

• Methotrexate could cause drowsiness, dizziness, or blurred vision. These effects may be worse if you get it with alcohol or certain medicines. Use Methotrexate with caution. Do not drive or perform other possibly unsafe tasks unless you understand how you reply to it.

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• Check with your physician before you consume alcohol while you're taking Methotrexate.

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• Nausea, vomiting, and decrease of appetite are routine with Methotrexate. Ask your physician or pharmacist for ways to decrease these effects if they occur.

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• If vomiting or diarrhea occurs, you will need to take care not to become dehydrated. Contact your doctor for instructions.

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• Methotrexate may cause you to become sunburned quicker. Avoid the sun, sunlamps, or tanning booths before you know how you answer Methotrexate. Use a sunscreen or wear protective clothing in the event you must be outside for more than a limited time.

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• Methotrexate may slow up the quantity of clot-forming cells (platelets) with your blood. Avoid activities that could potentially cause bruising or injury. Tell a medical expert if you have unusual bruising or bleeding. Tell your doctor when you have dark, tarry, or bloody stools.

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• Methotrexate may lower the ability of your respective body to fight infection. Avoid experience of those who have colds or infections. Tell your doctor in the event you notice signs of infection like fever, sore throat, rash, or chills.

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• Do not be given a live vaccine (eg, measles, mumps) while you are taking Methotrexate. Talk with your doctor when you get any vaccine.

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• Men taking Methotrexate would be wise to use a condom when having sex with a woman who may become pregnant. Do this provided you're taking Methotrexate as well as for 3 months once you stop taking it.

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• Do NOT take over the recommended dose or use more than prescribed without checking with your physician.
• Lab tests, including albumin levels, complete blood counts, and liver, lung, and kidney function, could possibly be performed while you use Methotrexate. These tests might be used to monitor your trouble or pay attention to unwanted effects. Be sure to keep all doctor and lab appointments.

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• Use Methotrexate with caution inside elderly; they could possibly be more sensitive to its effects.

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• Methotrexate should be combined with warning in kids younger than 2 years old; safety and effectiveness during these children haven't been confirmed.

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• Pregnancy and breast-feeding: Methotrexate could potentially cause birth defects and fetal and newborn death in the event you take it while you're pregnant. Do not conceive while you are using it. Use an effective kind of contraceptive while you adopt Methotrexate as well as a minimum of 1 ovulatory cycle after you stop taking it. If you think you could possibly be pregnant, contact your medical professional straight away. Methotrexate is located in breast milk. Do not breast-feed while taking Methotrexate.

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