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Uses

INDICATIONS

Indinavir is surely an antiviral medication in the gang of HIV medicines called protease (PRO-tee-ayz) inhibitors. Indinavir prevents human immunodeficiency virus (HIV) cells from multiplying within you. It is employed to treat HIV, that causes acquired immunodeficiency syndrome (AIDS). Indinavir is not a cure for HIV or AIDS.

INSTRUCTIONS

Take indinavir the same manner it was prescribed in your case. Do not go ahead and take medication in larger amounts, or go for more than recommended because of your doctor. Follow the directions on your prescription label.

This medication is sold with patient instructions for effective and safe use. Follow these directions carefully. Ask a medical expert or pharmacist for those who have questions.
Take indinavir with a full glass (8 ounces) of water or skim milk. You could also drink juice, coffee, or tea with this medication. Drink at the very least 6 servings of water daily to prevent kidney stones when you are taking indinavir. Indinavir needs to be taken on a clear chair stomach, no less than one hour before or 2 hours from a meal.

If you prefer to make medication with food, eat simply a light meal, including dry toast with jelly, or corn flakes with skim milk and sugar. Avoid eating a high-fat meal.

It is very important to use indinavir regularly to obtain the most benefit. Get your prescription refilled before you run out of drugs completely.

To be sure prescription drugs helps your trouble, your blood will need to be tested often. Your liver function could also should be tested. Do not miss any scheduled visits to your medical professional.

HIV/AIDS is generally treated using a combination of different drugs. To best treat your condition, utilize all of the medications as directed from your doctor. Be sure to read the medication guide or patient instructions provided with each of the medications. Do not improve your doses or medication schedule without advice from your medical professional. Every person with HIV or AIDS should remain underneath the proper care of a physician.

Take the missed dose whenever you remember and take your next dose with the regularly scheduled time. If you are more than a couple of hours late in taking your indinavir, skip the missed dose and consider the next regularly scheduled dose. Do not take extra medicine to generate in the missed dose.

DOSAGE

Usual Adult Dose for HIV Infection
800 mg orally every 8 hours or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours.


Usual Adult Dose for Nonoccupational Exposure
800 mg orally every 8 hours or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours.
Duration: Prophylaxis should be initiated as soon as possible, within 72 hours of exposure, and continued for 28 days.
Indinavir plus ritonavir plus 2 NRTIs is probably the alternative regimens recommended for nonoccupational postexposure HIV prophylaxis.


Usual Adult Dose for Occupational Exposure
800 mg orally every 8 hours 800 mg orally every 8 hours plus lamivudine-zidovudine,
or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours plus lamivudine-zidovudine.
Duration: Therapy must start promptly, preferably within 1 to a couple of hours postexposure. The exact duration of therapy may vary in line with the institution's protocol.

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Liver Dose Adjustments
Mild to moderate hepatic insufficiency: 600 mg orally every 8 hours.


Dose Adjustments
Consider reducing the dose to 600 mg every 8 hours if delavirdine, itraconazole, or ketoconazole are administered concomitantly. Increase the dose to 1000 mg every 8 hours if rifabutin emerged concurrently, and decrease the rifabutin dose by half.
Precautions

Strict adherence to the prescribed dose is essential. Patients ought not alter the dose or discontinue therapy without conferring with their physician.

Adequate hydration (1.5 liters/day) is important during therapy to lessen potential risk of nephrolithiasis. A brief interruption (usually 1 to 3 days) or total discontinuation might be necessary if nephrolithiasis occurs.

Discontinue indinavir if hemolytic anemia occurs. Consider discontinuation if severe leukocyturia develops.

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STORAGE

Store indinavir at room temperature from moisture and warmth. Keep the capsules of their original container, along with the packet of moisture-absorbing preservative that incorporates indinavir capsules.

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Side Effects

Get emergency medical help for those who have some of these indications of an allergic reaction: hives; lack of breath; swelling of your face, lips, tongue, or throat. Stop taking indinavir and call your physician simultaneously in case you have these serious side effects:

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Less serious negative effects may include:

This is not a complete set of unwanted effects and others may occur. Tell your physician about any unusual or bothersome side-effect.

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Precautions

Do not take this medication if you're allergic to indinavir.
Do not take indinavir with amiodarone (Cordarone, Pacerone), cisapride (Propulsid), pimozide (Orap), alprazolam (Xanax), oral midazolam (Versed), triazolam (Halcion), or ergot medicines such as ergotamine (Ergomar, Cafergot), dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), or methylergonovine (Methergine). These drugs could cause life-threatening unwanted effects if you use them when you are taking indinavir.

Before taking indinavir, tell a medical expert if you're allergic to the drugs, or for those who have:

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If you have some of these conditions, you may need a dose adjustment or special tests to safely take indinavir.
FDA pregnancy category C. This medication could be bad for an baby. Tell your doctor should you be pregnant or want to become pregnant during treatment. HIV may be passed for the baby if your mother just isn't properly treated during pregnancy. Take all of one's HIV medicines as directed to overcome your infection while you are pregnant.

Your name may must be from an antiviral pregnancy registry once you start using this medication.
You shouldn't breast-feed when you are using indinavir. Women with HIV or AIDS ought not breast-feed in any way. Even if your infant is born without HIV, might even pass the herpes simplex virus for the baby with your breast milk.

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