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Precautions

Do NOT use Duetact if:

• you might be allergic to the ingredient in Duetact
• you've moderate to severe heart failure, liver problems or abnormal liver function tests, certain severe problems linked to diabetes (eg, diabetic ketoacidosis, diabetic coma), moderate to severe burns, or extremely high blood acid levels (acidosis)
• you've type 1 diabetes
• you consider bosentan.

Contact a medical expert or physician immediately if these affect you.

Some medical conditions may connect to Duetact. Tell your medical professional or pharmacist when you have any medical conditions, in particular when any with the following apply to you:

• if you happen to be pregnant, intending to get pregnant, or are breast-feeding
• in the event you consider any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have had an extreme hypersensitivity (eg, severe rash, hives, breathing difficulties, dizziness) to any other sulfonamide medicine including acetazolamide, celecoxib, certain diuretics (eg, hydrochlorothiazide), glipizide, probenecid, sulfamethoxazole, valdecoxib, or zonisamide
• in case you have a history of kidney, thyroid, heart, or circulation problems; anemia, stroke; certain hormonal problems (eg, adrenal or pituitary problems, syndrome of inappropriate secretion of antidiuretic hormone [SIADH]); low blood sodium levels; or lower levels associated with an enzyme called glucose 6-phosphate dehydrogenase (G6PD)
• for those who have stomach or bowel problems (eg, stomach or bowel blockage, stomach paralysis), are drinking alcoholic beverages, or experienced poor nutrition
• if you have inadequate health, an increased fever, an intense infection, severe diarrhea, high blood acid levels, or brain or neurological system problems, or also have an intense injury
• if you have a history of bladder cancer, bone fracture, low calcium intake, or weak bones (eg, osteoporosis)
• in case you have swelling problems (edema) or certain eye problems (macular edema)
• if you may be having surgery.

Some medicines may interact with Duetact. Tell your medical provider in case you take some other medicines, especially any of the following:

• Bosentan because liver problems may occur, as well as the effectiveness of both medicines might be decreased
• Beta-blockers (eg, propranolol) for the reason that risk of low blood glucose levels might be increased. They may also hide certain signs of low blood glucose levels and make it more difficult to notice
• Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), azole antifungals (eg, miconazole, ketoconazole), chloramphenicol, clarithromycin, clofibrate, disopyramide, fenfluramine, fluoxetine, insulin, monoamine oxidase inhibitors (MAOIs) (eg, phenelzine), nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), phenylbutazone, probenecid, quinolone antibiotics (eg, ciprofloxacin), salicylates (eg, aspirin), and sulfonamides (eg, sulfamethoxazole) for the reason that chance of low blood sugar might be increased
• Calcium channel blockers (eg, diltiazem), corticosteroids (eg, prednisone), decongestants (eg, pseudoephedrine), diazoxide, diuretics (eg, furosemide, hydrochlorothiazide), estrogens, hormonal contraceptives (eg, contraception pills), isoniazid, niacin, phenothiazines (eg, promethazine), phenytoin, rifamycins (eg, rifampin), sympathomimetics (eg, albuterol, epinephrine), or thyroid supplements (eg, levothyroxine) simply because they may decrease Duetact's effectiveness, resulting in high blood glucose levels
• Gemfibrozil because blood glucose could possibly be increased or decreased
• Anticoagulants (eg, warfarin) as their effectiveness might be decreased or the chance of their unwanted effects could be increased by Duetact.

This might not be an entire listing of all interactions that could occur. Ask your medical provider if Duetact may interact with other medicines which you take. Check with your doctor before starting, stop, or customize the dose from a medicine.

Important safety information:

• Duetact might cause drowsiness, dizziness, blurred vision, or lightheadedness. These effects may be worse if you get it with alcohol or certain medicines. Use Duetact with caution. Do not drive or perform other possible unsafe tasks and soon you discover how you answer it.
• Do not are drinking alcoholic beverages whilst you consider Duetact; it might raise the likelihood of low blood glucose. Rarely, alcohol may talk with Duetact and cause a serious reaction with symptoms like flushing, nausea, vomiting, dizziness, or stomach pain. Discuss questions or concerns together with your doctor.
• Carry an ID card at all times saying you've diabetes.
• Proper dieting and exercise are crucial so that you can slim down and make it well. Follow the exercise and dieting program directed at you because of your doctor.
• Check your blood sugar levels levels as directed from your doctor. If they are often higher or less than they will be and also you take Duetact the same manner prescribed, tell your medical professional.
• It could be harder to manage your blood glucose levels in times of stress including fever, infection, injury, or surgery. Talk using your doctor about how precisely to regulate your blood glucose levels if these occur. Do not customize the dose of your respective medicine without checking using your doctor.
• Do not take greater than the recommended dose without checking using your doctor.
• Duetact could cause low blood sugar levels levels. Low blood glucose may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your heartbeat faster; you could make your vision change; give you a headache, chills, or tremors; or cause you to more hungry. It is often a good idea to hold the best source of glucose (eg, tablets or gel) to help remedy low blood sugar. If this is not available, you should eat or drink a simple source of sugar like table sugar, honey, candy, orange juice, or non-diet soda. This will raise the blood glucose levels level quickly. Tell your medical professional immediately in such a circumstance. To prevent low blood glucose levels, eat meals as well daily and do not skip meals.
• Risk of low blood sugar could possibly be increased by severe or prolonged exercise, having a drink, or skipping meals.
• Duetact has a sulfonylurea. It may improve the likelihood of death from cardiovascular disease. Talk with your doctor about the benefits and risks of this or another therapies to treat your trouble.
• Duetact could potentially cause ovulation in ladies who may have not reached menopause but do not ovulate. To avoid pregnancy, be sure to work with effective contraceptive when using Duetact.
• Duetact might cause you to become sunburned easier. Avoid the sun, sunlamps, or tanning booths before you recognize how you answer Duetact. Use a sunscreen or wear protective clothing in case you must be outside for greater than a limited time.
• Tell your doctor or dentist that you take Duetact before you have any medical or dentistry, emergency care, or surgery.
• Duetact might be associated with an increased chance of bladder cancer. Discuss questions or concerns with your doctor.
• An increased incidence of bone fracture may be reported ladies who take Duetact. Tell your doctor when you have a good reputation for bone fracture, low calcium intake, or weak bones (eg, osteoporosis). Tell your doctor without delay in case you experience any unusual bone pain.
• Lab tests, including fasting blood glucose, hemoglobin A_1c, liver function, and eye exams, could be performed when you use Duetact. These tests may be used to monitor your problem or pay attention to negative effects. Be sure to keep all doctor and lab appointments.
• Use Duetact with caution inside elderly; they could be more sensitive to its effects, specially the probability of heart disease or low blood glucose.
• Duetact should not be employed in children; safety and effectiveness in kids haven't been confirmed.
• Pregnancy and breast-feeding: Duetact could cause trouble for the fetus or newborn. If you think you could be pregnant, get hold of your doctor. You will need to discuss the advantages and risks of using Duetact while you happen to be pregnant. It is not known if Duetact is located in breast milk. Do not breastfeed while taking Duetact.

When used for a long Duetact may not are well. If your blood sugar levels may be manageable and then becomes hard to manage, contact your doctor. Do not affect the dose of your medicine without checking along with your doctor.