See also Warning section.

This medicine is used to take care of mental/mood that is certain (schizophrenia, schizoaffective disorders). Clozapine is a psychiatric medication (anti-psychotic type) that works by helping to restore the balance of particular natural substances (neurotransmitters) into the brain.

Clozapine decreases hallucinations and helps prevent committing suicide in individuals who are most likely to try to harm on their own. It will help you to definitely think more clearly and definitely about yourself, feel less nervous, and indulge in everyday life.

How to use Clozaril

If you are utilising the liquid form with this medication, read the Patient Information Leaflet if available from your pharmacist before you begin taking clozapine and each time you get a refill. If you have any relevant concerns, ask your doctor or pharmacist.

Just take this medicine by mouth with or without food, as directed by your doctor. If you're taking the tablets that dissolve in the mouth, remove each tablet carefully from the blister pack immediately before taking your dose. Allow the tablets to dissolve on your swallow and tongue. You do not need to take the dissolving tablets with water. Discard any dissolving tablets that are formerly subjected to air due to packaging that is opened/damaged. Do not save yourself them for your following dose.

If you use the form that is liquid of medication, shake the bottle well for 10 seconds before each use. Carefully measure the dose using a measuring device/spoon that is special. Don't use a household spoon because you may not obtain the correct dose.

It is critical to begin taking this drug at a dose that is low increasing your dose slowly, to lessen adverse effects such as dizziness, drowsiness and seizures. Follow your doctor's instructions exactly. Your dosage is based on your condition that is medical and to therapy. Since clozapine can cause a decrease in white blood cells, you will need to get blood tests done regularly as directed. Be sure to keep all appointments for these laboratory tests. (See also Notes section.)

If you miss your doses for longer than a day or two, consult your doctor for a new schedule to get back to the dose you were on (see Missed Dose section). Use this medication regularly in order to get the most benefit from it. To simply help you remember, make use of it at the same time(s) each day.

Do not stop taking clozapine without consulting your doctor. Some conditions may become worse when the drug is suddenly stopped. Also, you might experience symptoms such as severe sweating, headache, nausea, vomiting, and diarrhea. To avoid these symptoms while you're stopping treatment with this drug, your doctor may reduce your dosage gradually. Check with your pharmacist or doctor for more details. Report any new or symptoms that are worsening away.

It might take several weeks ahead of the full benefit of this drug takes effect. Inform your physician if for example the condition persists or worsens.

Part Effects

See section that is also warning.

Drooling, drowsiness, dizziness, headache, shaking tremor that is(, vision problems (e.g., blurred vision), weight gain, and constipation may occur. Many of these effects (especially drowsiness) lessen as your body gets used to the medication. If any of these effects persist or worsen, contact your pharmacist or doctor promptly.

To prevent constipation, keep a diet adequate in fiber, drink plenty of water, and exercise. If you become constipated when using this drug, consult your pharmacist for assistance in selecting a laxative (e.g., stimulant-type with stool softener).

Keep in mind that your doctor has prescribed this medication she has judged that the benefit to you is greater than the risk of adverse effects because he or. Many people using this medication do not have adverse that is serious.

This medication may make your blood rarely sugar level rise, which can cause or worsen diabetes. Rarely, very conditions that are serious as diabetic coma may occur. Tell your medical practitioner right away if you develop symptoms of high blood sugar levels, such as increased thirst and urination. In the event that you already have diabetes, make sure to check your bloodstream sugars regularly. Your medical professional may need certainly to adjust your diabetes medication, exercise program, or diet.

This medication may also cause weight that is significant and a rise in your cholesterol (or triglyceride) levels. These effects, along with diabetic issues, may increase your risk for developing heart condition. Talk about the dangers and advantages of treatment with your physician.

Tell your physician right away if you have any serious adverse effects, including: facial/muscle twitching, seizures, uncontrollable motions.

Get help that is medical away if you have any very serious part results, including: severe dizziness, fainting, mental/mood changes, trouble respiration with exercise, sudden weakness, pain/redness/swelling of the arms/legs, persistent nausea/vomiting, stomach/abdominal pain, yellowing of eyes/skin.

This medication may rarely cause a tremendously condition that is serious neuroleptic malignant syndrome (NMS). Get medical help right away if you have any of the following symptoms: temperature, muscle tissue stiffness/pain/tenderness/weakness, severe tiredness, severe confusion, sweating, fast/irregular heartbeat, dark urine, change in the level of urine.

A tremendously serious reaction that is allergic this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious reaction that is allergic include: rash, itching/swelling (especially of the face/tongue/throat), serious dizziness, trouble breathing.

This is simply not a list that is complete of side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your physician for medical advice about side results. You may report side effects to Food And Drug Administration at 1-800-FDA-1088 or at

In Canada - Call your doctor for medical advice about adverse effects. You could report side effects to Health Canada at 1-866-234-2345.


See also Warning and adverse Effects parts.

Before taking clozapine, inform your medical practitioner or pharmacist in the event that you have any other allergies if you are allergic to it or. This product may contain inactive ingredients, which may cause allergic reactions or other issues. Confer with your pharmacist for additional information.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: history of blood disorders (such as leukemia, low white blood cell count), bowel problems (such as paralytic ileus, irritable bowel syndrome ), difficulty in breathing, diabetes/family history of diabetes, high cholesterol/triglyceride levels, glaucoma, heart problems, renal problems, liver problems, obesity/family history of obesity, seizures, trouble urinating (such as prostate problems).

Clozapine may cause an ailment that affects the center rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely deadly) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that require medical attention right away.

The risk of QT prolongation may be increased when you have certain conditions that are medical are taking other drugs which will affect the center rhythm. Before using clozapine, tell your doctor or pharmacist of most the drugs you take and if you have some of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation into the EKG), genealogy and family history of certain heart related illnesses (QT prolongation in the EKG, unexpected cardiac death).

Low levels of potassium or magnesium in the blood may increase your risk also of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about making use of clozapine safely.

This drug could make you dizzy or drowsy or cause blurred vision. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely. Limit beverages that are alcoholic.

Tell your medical professional if you are a descendent of Ashkenazi Jews because you may be at a higher risk for a drop in your white blood cells.

Before having surgery, tell your doctor or dentist that you are by using this medication.

Liquid items or tablets that are dissolving contain sugar and/or aspartame. Liquid products may contain alcohol also. Caution is advised you to limit/avoid these substances in your diet if you have diabetes, liver disease, phenylketonuria (PKU), or any other condition that requires. Ask your pharmacist or doctor about applying this product safely.

Older grownups may be more responsive to the relative part aftereffects of this drug, especially constipation, dizziness, and QT prolongation (see above). Dizziness can increase the danger of falling.

During pregnancy, this medicine should be used only when plainly needed. Babies born to moms who purchased this medication over the last 3 months of pregnancy may rarely develop symptoms including muscle stiffness or shakiness, drowsiness, feeding/breathing difficulties, or constant crying. If you notice any of these symptoms in your newborn especially during their month that is first the doctor right away.

Since untreated mental/mood problems (such as for example schizophrenia, schizoaffective disorders) can be a condition that is serious do not stop taking this medication unless directed by your doctor. You may be pregnant, immediately discuss with your doctor the benefits and risks of using this medication during pregnancy if you are planning pregnancy, become pregnant, or think.

This medicine may pass into breast milk while having effects that are undesirable a nursing infant. Breast feeding is not advised while taking clozapine. Consult your physician before breast-feeding.

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