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Uses

INDICATIONS

Chloroquine is indicated for that suppressive treatment as well as acute attacks of malaria because of P. vivax, P.malariae, P. ovale, and susceptible strains of P. falciparum. The drug is also indicated to the treatment of extraintestinal amebiasis.

INSTRUCTIONS

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Take chloroquine with meals or milk to cut back stomach upset, unless otherwise directed through your doctor.

t is critical that you take chloroquine only as directed. Do not take more of it, do not take it more often, and don't take it for a longer time than your doctor ordered. To do so could raise the potential for serious unwanted effects.

If you take chloroquine to maintain you from getting malaria, keep taking it for the full-time of treatment. If you have malaria, you must still keep taking chloroquine for your full-time of treatment even though you commence to feel better right after days. This will help in order to up your infection completely. If you stop taking chloroquine prematurily ., your symptoms may return.

Chloroquine is most effective when you go on it on the regular schedule. For example, if you're to go weekly to stop malaria, it is best to go on it on the same day weekly. Or should you be to adopt two doses each day, one dose could be taken with breakfast as well as the other while using evening meal. Make sure that you simply do not miss any doses. If you've any questions about this, seek advice from your wellbeing care professional.

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If you miss a dose of chloroquine, get it at the earliest opportunity. However, if it's almost time for your forthcoming dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

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DOSAGE 

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The dosage of chloroquine phosphate is usually expressed when it comes to equivalent chloroquine base. Each 500 mg tablet of ARALEN contains the same as 300 mg chloroquine base. In infants and children the dosage is preferably calculated by weight.

Malaria: Suppression - Adult Dose: 500 mg (= 300 mg base) on exactly the same day of per week.

Pediatric Dose: The weekly suppressive dosage is 5 mg calculated as base, per kg of bodyweight, but shouldn't exceed the adult dose no matter weight.

If circumstances permit, suppressive therapy should start a couple weeks before exposure. However, failing this in older adults, an initial double (loading) dose of 1 g (= 600 mg base), or perhaps children 10 mg base/kg may be consumed two divided doses, six hours apart. The suppressive therapy should be continued for 8 weeks after leaving the endemic area.
For Treatment of Acute Attack.

Adults: An initial dose of just one g (= 600 mg base) as well as yet another 500 mg (= 300 mg base) after six to eight hours as well as a single dose of 500 mg (= 300 mg base) on each of two consecutive days. This represents an overall dose of 2.5 g chloroquine phosphate or 1.5 g base in three days.

The dosage for adults of low bodyweight and then for infants and children should be determined as follows:

First dose: 10 mg base per kg (although not exceeding just one dose of 600 mg base).

Second dose: (6 hours after first dose) 5 mg base per kg (but not exceeding a single dose of 300 mg base).

Third dose: (twenty four hours after first dose) 5 mg base per kg.

Fourth dose: (36 hours after first dose) 5 mg base per kg.

For radical cure of vivax and malariae malaria concomitant therapy having an 8-aminoquinoline compound is necessary.

Extraintestinal Amebiasis: Adults,1 g (600 mg base) daily for just two days, accompanied by 500 mg (300 mg base) daily for about 2-3 weeks. Treatment is usually combined with an effective intestinal amebicide.

STORAGE 

Store the medicine in the closed container at room temperature, faraway from heat, moisture, and direct light. Keep from freezing.

Keep out from the reach of children.

Do not keep outdated medicine or medicine no more needed.

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Side Effects

Along with its needed effects, medicine could potentially cause some unwanted side effects. Although not most of these side effects may occur, should they happen they could need medical assistance. When chloroquine is utilized in short amounts of time, unwanted effects are frequently rare. However, when it is utilized for quite a long time and/or in high doses, negative effects will occur and could possibly be serious.

Check with a medical expert immediately if the following unwanted effects occur:
Less common

Blurred vision
alteration of vision
eye pain
loss of vision
Rare
Black, tarry stools
blood in urine or stools
convulsions (seizures)
cough or hoarseness
feeling faint or lightheaded
fever or chills
increased muscle weakness
lower back or side pain
mood or other mental changes
painful or difficult urination
pinpoint red spots on skin
ringing or buzzing in ears or any decrease of hearing
sore throat
unusual bleeding or bruising
unusual tiredness or weakness
Symptoms of overdose
Drowsiness
headache
increased excitability

Note: The negative effects in the Less Common category above might also occur or get worse as soon as you stop taking chloroquine.

Some negative effects may occur that usually usually do not need medical help. These unwanted effects might go away during treatment as your body adjusts for the medicine. Also, your wellbeing care professional could possibly be able to tell you about ways to avoid or reduce some side effects. Check with your health care professional if any of these negative effects continue or are bothersome or if you've questions about them:


More common

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Diarrhea
difficulty in seeing to read
headache
itching (more common in black patients)
lack of appetite
nausea or vomiting
stomach cramps or pain
Less common
Bleaching of hair or increased hair loss
blue-black discoloration of skin, fingernails, or inside mouth
skin rash

Other negative effects unlisted may also happen in some patients. If you notice some other effects, consult your medical practioner.

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Precautions

If you'll be taking chloroquine for quite a long time, it is very important that your physician check you at regular visits for almost any blood problems or muscle weakness that could possibly be due to chloroquine. In addition, seek advice from your medical professional immediately if blurred vision, difficulty in reading, or some other alternation in vision occurs during or after treatment. Your doctor may want you to have your vision checked by an ophthalmologist (eye doctor).

If your symptoms do not improve within a few days or should they become worse, consult a medical expert.

Make sure you are aware how you answer chloroquine when you drive, use machines, or a single thing else that could be dangerous if you're not able to see well.

Chloroquine might cause blurred vision, difficulty in reading, and other change in vision. It can also cause a lot of people to become lightheaded.

If these reactions are especially bothersome, consult a medical expert.

Certain medicines shouldn't be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines could also cause interactions to happen. Discuss along with your doctor the application of your medicine with food, alcohol, or tobacco.

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There are not any adequate and well-controlled studies evaluating the security and efficacy of chloroquine in pregnant women. Usage of chloroquine while pregnant ought to be avoided except in the suppression or management of malaria when inside judgment of the physician the main benefit outweighs the potential risk towards the fetus.

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