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Baclofen is used for treating spasm of skeletal muscles that can cause muscle clonus, rigidity, and pain because of multiple sclerosis. Baclofen relaxes skeletal muscles, the muscles that move the skeleton (also called striated muscle). Chemically, Baclofen is related to gamma-aminobutyric acid (GABA), a naturally-occurring neurotransmitter inside brain. Neurotransmitters are chemicals that nerves use to speak collectively. GABA released by some nerves causes the experience of other nerves to reduce. It is thought that Baclofen, acting like GABA, blocks the adventure of nerves inside the section of the brain that controls the contraction and relaxation of skeletal muscle. Baclofen was approved by the FDA in November, 1977.
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The usual starting dose of Baclofen for adults is 5 mg 3 x daily. Based on the response, the dose might be increased gradually every 72 hours to a maximum of 80 mg/day in a number of doses.
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Baclofen should be stored between 15°C (59°F) and 30°C (86°F). Keep Baclofen from the reach of children.
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Baclofen might cause drowsiness, weakness, dizziness, headache, seizures, nausea, vomiting, low blood pressure, constipation, confusion, respiratory depression, inability to sleep, and increased urinary frequency or urinary retention.
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Abrupt discontinuation of oral Baclofen could potentially cause seizures and hallucinations. Abrupt discontinuation of intrathecal Baclofen may result in high fever, rebound spasticity, muscle rigidity, and rhabdomyolysis (muscle breakdown).
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Use of Baclofen with drugs which depress the function of nerves may result in additional lowering of brain function.
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In addition on the chance of depressing brain function, using Baclofen and tricyclic antidepressants (e.g., Elavil, Sinequan) together might cause muscle weakness.
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Use of Baclofen and monoamine oxidase inhibitors (e.g. Nardil, Parnate) may result in greater depression of brain function along with low blood pressure level.
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As Baclofen can increase blood sugar, doses of antidiabetic drugs may need to be adjusted when Baclofen is taken.
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The usage of Baclofen by women that are pregnant hasn't been evaluated.
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Baclofen might be detected inside the breast milk of mothers taking oral Baclofen. No facts are entirely on a good Baclofen within the breast milk of mothers receiving Baclofen intrathecally.
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